藥物交互作用
Chloroprocaine + Timolol
嚴重程度: 中度
Chloroprocaine and Timolol: moderate interaction.
最後更新
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摘要
If chloroprocaine is given with epinephrine, nonselective beta-blockade such as timolol can leave alpha-mediated pressor effects unopposed. This can produce hypertension with reflex bradycardia.
用白話說明這項交互作用的意義
Chloroprocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroprocaine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
為什麼會發生
Timolol blocks beta-2 vasodilation, leaving epinephrine's alpha-mediated vasoconstriction unopposed.
處置方式
Continue the beta-blocker perioperatively, use the lowest epinephrine dose or an epinephrine-free preparation, and monitor blood pressure and heart rate.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Timolol 的其他交互作用
Chloroprocaine 的其他交互作用
常見問題
Can I take Chloroprocaine with Timolol?
MediHelp rates the interaction as moderate. Chloroprocaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. If chloroprocaine is given with epinephrine, nonselective beta-blockade such as timolol can leave alpha-mediated pressor effects unopposed. This can produce hypertension with reflex bradycardia.
How serious is the interaction between Chloroprocaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue the beta-blocker perioperatively, use the lowest epinephrine dose or an epinephrine-free preparation, and monitor blood pressure and heart rate.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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