藥物交互作用
Chlorothiazide + Sotalol
嚴重程度: 嚴重
Chlorothiazide and Sotalol: major interaction.
最後更新
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摘要
Thiazide diuretics can cause hypokalemia and hypomagnesemia. These electrolyte disturbances increase the risk of QT prolongation and torsade de pointes with sotalol.
用白話說明這項交互作用的意義
Chlorothiazide and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorothiazide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
為什麼會發生
Diuretic-induced hypokalemia and hypomagnesemia potentiate sotalol's QT-prolonging effect.
處置方式
Check potassium and magnesium before and during therapy, replace deficits, and monitor the ECG for QTc prolongation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Sotalol 的其他交互作用
Chlorothiazide 的其他交互作用
常見問題
Can I take Chlorothiazide with Sotalol?
MediHelp rates the interaction as major. Chlorothiazide and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thiazide diuretics can cause hypokalemia and hypomagnesemia. These electrolyte disturbances increase the risk of QT prolongation and torsade de pointes with sotalol.
How serious is the interaction between Chlorothiazide and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during therapy, replace deficits, and monitor the ECG for QTc prolongation.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
