藥物交互作用
Chlorothiazide + Lithium
嚴重程度: 嚴重
Chlorothiazide and Lithium: major interaction.
最後更新
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摘要
Thiazide diuretics reduce renal lithium clearance and can raise serum lithium, leading to toxicity with tremor, confusion, vomiting and ataxia.
用白話說明這項交互作用的意義
Chlorothiazide and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorothiazide belongs to Cardiovascular; Lithium belongs to Central Nervous System.
為什麼會發生
Thiazide-induced sodium depletion increases proximal tubular reabsorption of lithium.
處置方式
Avoid if possible. If used, reduce the lithium dose and monitor serum lithium closely after starting, with attention to sodium and renal function.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Lithium 的其他交互作用
Chlorothiazide 的其他交互作用
常見問題
Can I take Chlorothiazide with Lithium?
MediHelp rates the interaction as major. Chlorothiazide and Lithium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Thiazide diuretics reduce renal lithium clearance and can raise serum lithium, leading to toxicity with tremor, confusion, vomiting and ataxia.
How serious is the interaction between Chlorothiazide and Lithium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, reduce the lithium dose and monitor serum lithium closely after starting, with attention to sodium and renal function.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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