藥物交互作用
Chlorothiazide + Hydrochlorothiazide-lisinopril
嚴重程度: 嚴重
Chlorothiazide and Hydrochlorothiazide-lisinopril: major interaction.
最後更新
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摘要
Chlorothiazide duplicates the thiazide component already present and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without added benefit.
用白話說明這項交互作用的意義
Chlorothiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorothiazide belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
為什麼會發生
Duplicate inhibition of the distal tubule sodium-chloride cotransporter with additive electrolyte loss and volume depletion.
處置方式
Avoid combining two thiazides and discontinue one. Monitor electrolytes and renal function if overlap is unavoidable.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Hydrochlorothiazide-lisinopril 的其他交互作用
- Dofetilide + Hydrochlorothiazide-lisinopril 禁忌併用
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan 禁忌併用
- Amifostine + Hydrochlorothiazide-lisinopril 嚴重
- Amiloride + Hydrochlorothiazide-lisinopril 嚴重
- Benazepril + Hydrochlorothiazide-lisinopril 嚴重
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril 嚴重
Chlorothiazide 的其他交互作用
常見問題
Can I take Chlorothiazide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Chlorothiazide and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorothiazide duplicates the thiazide component already present and increases the risk of hypokalemia, hyponatremia, hypotension and renal impairment without added benefit.
How serious is the interaction between Chlorothiazide and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides and discontinue one. Monitor electrolytes and renal function if overlap is unavoidable.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
