藥物交互作用
Candesartan-hydrochlorothiazide + Chlorothiazide
嚴重程度: 嚴重
Candesartan-hydrochlorothiazide and Chlorothiazide: major interaction.
最後更新
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摘要
Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
用白話說明這項交互作用的意義
Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Chlorothiazide belongs to Cardiovascular.
為什麼會發生
Additive diuretic and electrolyte effects of two thiazide diuretics at the distal tubule.
處置方式
Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Candesartan-hydrochlorothiazide 的其他交互作用
Chlorothiazide 的其他交互作用
常見問題
Can I take Candesartan-hydrochlorothiazide with Chlorothiazide?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Chlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorothiazide duplicates the thiazide component already present in the combination product. This raises the risk of hypokalemia, hyponatremia, volume depletion, hypotension and renal impairment without clear added benefit.
How serious is the interaction between Candesartan-hydrochlorothiazide and Chlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides and stop one. Monitor electrolytes and renal function if the combination cannot be avoided.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
