藥物交互作用
Chlorpropamide + Ethanol
嚴重程度: 嚴重
Chlorpropamide and Ethanol: major interaction.
最後更新
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摘要
Chlorpropamide is the sulfonylurea most strongly associated with a disulfiram-like reaction with alcohol, producing flushing, headache, nausea and palpitations. Alcohol also increases the risk of prolonged hypoglycemia in patients on this long-acting drug.
用白話說明這項交互作用的意義
Chlorpropamide and Ethanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Inhibition of aldehyde dehydrogenase leads to acetaldehyde accumulation, while alcohol-induced suppression of gluconeogenesis adds to sulfonylurea hypoglycemia.
處置方式
Counsel the patient to avoid alcohol completely; consider switching to a newer sulfonylurea or another class if abstinence is unlikely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlorpropamide 的其他交互作用
常見問題
Can I take Chlorpropamide with Ethanol?
MediHelp rates the interaction as major. Chlorpropamide and Ethanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Chlorpropamide is the sulfonylurea most strongly associated with a disulfiram-like reaction with alcohol, producing flushing, headache, nausea and palpitations. Alcohol also increases the risk of prolonged hypoglycemia in patients on this long-acting drug.
How serious is the interaction between Chlorpropamide and Ethanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to avoid alcohol completely; consider switching to a newer sulfonylurea or another class if abstinence is unlikely.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Exenatide, Insulin degludec-insulin aspart, Insulin degludec-liraglutide. The full list is on the Chlorpropamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
