藥物交互作用
Chlorpropamide + Ofloxacin
嚴重程度: 嚴重
Chlorpropamide and Ofloxacin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Ofloxacin can cause severe hypoglycemia or hyperglycemia in patients taking sulfonylureas. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged and may need hospital treatment.
用白話說明這項交互作用的意義
Chlorpropamide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpropamide belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
為什麼會發生
Fluoroquinolones stimulate insulin release by blocking pancreatic beta-cell ATP-sensitive potassium channels, adding to the sulfonylurea effect.
處置方式
Monitor blood glucose closely during ofloxacin therapy and consider reducing the sulfonylurea dose. Teach patients about hypoglycemia and use an alternative antibiotic in high-risk patients such as the elderly or those with renal impairment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Ofloxacin 的其他交互作用
Chlorpropamide 的其他交互作用
常見問題
Can I take Chlorpropamide with Ofloxacin?
MediHelp rates the interaction as major. Chlorpropamide and Ofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ofloxacin can cause severe hypoglycemia or hyperglycemia in patients taking sulfonylureas. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged and may need hospital treatment.
How serious is the interaction between Chlorpropamide and Ofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during ofloxacin therapy and consider reducing the sulfonylurea dose. Teach patients about hypoglycemia and use an alternative antibiotic in high-risk patients such as the elderly or those with renal impairment.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
