藥物交互作用
Cimetidine + Dasatinib
嚴重程度: 嚴重
Cimetidine and Dasatinib: major interaction.
最後更新
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摘要
Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
用白話說明這項交互作用的意義
Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cimetidine belongs to Gastrointestinal Tract; Dasatinib belongs to Oncology.
為什麼會發生
Weak CYP3A4 inhibition by cimetidine may increase dasatinib levels, while the rise in gastric pH decreases dasatinib dissolution and absorption.
處置方式
Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cimetidine 的其他交互作用
Dasatinib 的其他交互作用
常見問題
Can I take Cimetidine with Dasatinib?
MediHelp rates the interaction as major. Cimetidine and Dasatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cimetidine can raise dasatinib exposure through CYP3A4 inhibition, but as an H2 blocker it also lowers gastric acidity, which reduces dasatinib absorption because its solubility depends on acid. The net effect is unpredictable and may result in either toxicity or reduced efficacy.
How serious is the interaction between Cimetidine and Dasatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 blockers with dasatinib; use an antacid given at least 2 hours before or after dasatinib if acid suppression is needed. Monitor response and toxicity if combination cannot be avoided.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
