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藥物交互作用

Cisapride + Escitalopram

嚴重程度: 禁忌併用

Cisapride and Escitalopram: contraindicated interaction.

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僅供醫療專業人員參考。本頁為簡要摘要,並非醫療建議,亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Cisapride can cause dose-related torsades de pointes, and escitalopram also prolongs the QT interval in a dose-dependent fashion. The combination is contraindicated in the cisapride labelling.

用白話說明這項交互作用的意義

Cisapride and Escitalopram are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cisapride belongs to Gastrointestinal Tract; Escitalopram belongs to Central Nervous System.

證據等級: High

為什麼會發生

Additive QTc prolongation

處置方式

Do not co-administer; use a prokinetic without QT effect or an alternative antidepressant.

可向藥師詢問的問題

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用,即可解鎖 Cisapride 與 Escitalopram 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

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常見問題

Can I take Cisapride with Escitalopram?

MediHelp rates the interaction as contraindicated. Cisapride and Escitalopram are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cisapride can cause dose-related torsades de pointes, and escitalopram also prolongs the QT interval in a dose-dependent fashion. The combination is contraindicated in the cisapride labelling.

How serious is the interaction between Cisapride and Escitalopram?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a prokinetic without QT effect or an alternative antidepressant.

What other medicines interact with Cisapride?

MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.

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