藥物交互作用

Escitalopram + Phenelzine

嚴重程度: 禁忌併用

Escitalopram and Phenelzine: contraindicated interaction.

最後更新 12 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Phenelzine irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.

用白話說明這項交互作用的意義

Escitalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Escitalopram belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.

證據等級: High

為什麼會發生

Inhibition of monoamine oxidase combined with an SSRI activity leading to excess serotonergic stimulation

處置方式

Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Escitalopram 與 Phenelzine 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

建立免費帳號登入

在網頁版免費試用 Pro+ 14 天，無需信用卡。

常見問題

Can I take Escitalopram with Phenelzine?

MediHelp rates the interaction as contraindicated. Escitalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine irreversibly inhibits both MAO-A and MAO-B, so adding escitalopram (an SSRI) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.

How serious is the interaction between Escitalopram and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days between stopping either drug and starting the other.

What other medicines interact with Escitalopram?

MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.

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摘要