藥物交互作用
Escitalopram + Methylene blue
嚴重程度: 禁忌併用
Escitalopram and Methylene blue: contraindicated interaction.
最後更新
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摘要
Methylene blue inhibits monoamine oxidase A, and combining it with an SSRI can cause serotonin syndrome, which has been reported with intravenous use. Features include confusion, agitation, myoclonus, hyperthermia and autonomic instability.
用白話說明這項交互作用的意義
Escitalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Methylene blue inhibits MAO-A, raising serotonin levels on top of SSRI reuptake blockade.
處置方式
Avoid the combination in elective settings. If methylene blue is urgently needed, stop escitalopram and monitor for serotonin toxicity for up to 2 weeks or 24 hours after the last methylene blue dose, whichever comes first.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Escitalopram 的其他交互作用
常見問題
Can I take Escitalopram with Methylene blue?
MediHelp rates the interaction as contraindicated. Escitalopram and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A, and combining it with an SSRI can cause serotonin syndrome, which has been reported with intravenous use. Features include confusion, agitation, myoclonus, hyperthermia and autonomic instability.
How serious is the interaction between Escitalopram and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in elective settings. If methylene blue is urgently needed, stop escitalopram and monitor for serotonin toxicity for up to 2 weeks or 24 hours after the last methylene blue dose, whichever comes first.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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