藥物交互作用
Clarithromycin + Eliglustat
嚴重程度: 禁忌併用
Clarithromycin and Eliglustat: contraindicated interaction.
最後更新
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摘要
Clarithromycin strongly inhibits CYP3A4 and can substantially raise eliglustat exposure, which is associated with PR, QRS and QT interval prolongation and arrhythmia. The risk is highest in CYP2D6 poor or intermediate metabolizers and when CYP2D6 is also inhibited.
用白話說明這項交互作用的意義
Clarithromycin and Eliglustat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Eliglustat belongs to Miscellaneous.
為什麼會發生
Clarithromycin inhibits CYP3A4, a key metabolic pathway for eliglustat, increasing its plasma concentration.
處置方式
Avoid in CYP2D6 intermediate or poor metabolizers and in patients on CYP2D6 inhibitors; otherwise use a different antibiotic or reduce eliglustat dose per labeling with ECG monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clarithromycin 的其他交互作用
Eliglustat 的其他交互作用
常見問題
Can I take Clarithromycin with Eliglustat?
MediHelp rates the interaction as contraindicated. Clarithromycin and Eliglustat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin strongly inhibits CYP3A4 and can substantially raise eliglustat exposure, which is associated with PR, QRS and QT interval prolongation and arrhythmia. The risk is highest in CYP2D6 poor or intermediate metabolizers and when CYP2D6 is also inhibited.
How serious is the interaction between Clarithromycin and Eliglustat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 intermediate or poor metabolizers and in patients on CYP2D6 inhibitors; otherwise use a different antibiotic or reduce eliglustat dose per labeling with ECG monitoring.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
