藥物交互作用
Eliglustat + Posaconazole
嚴重程度: 禁忌併用
Eliglustat and Posaconazole: contraindicated interaction.
最後更新
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摘要
Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.
用白話說明這項交互作用的意義
Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
為什麼會發生
Posaconazole inhibits CYP3A4, a secondary eliglustat clearance pathway that becomes critical when CYP2D6 activity is low or inhibited.
處置方式
Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Posaconazole 的其他交互作用
Eliglustat 的其他交互作用
常見問題
Can I take Eliglustat with Posaconazole?
MediHelp rates the interaction as contraindicated. Eliglustat and Posaconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole increases eliglustat concentrations, which may prolong PR, QRS and QT intervals and cause arrhythmias. The effect is greater in CYP2D6 poor or intermediate metabolizers and when a CYP2D6 inhibitor is also taken.
How serious is the interaction between Eliglustat and Posaconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 poor or intermediate metabolizers and with any additional CYP2D6 inhibitor. In extensive metabolizers, follow labeling with a reduced eliglustat dose and ECG monitoring, or choose an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
