藥物交互作用
Clarithromycin + Lovastatin
嚴重程度: 禁忌併用
Clarithromycin and Lovastatin: contraindicated interaction.
最後更新
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摘要
Clarithromycin is a strong CYP3A4 inhibitor, and lovastatin depends almost entirely on CYP3A4 for clearance. Exposure rises many-fold, leading to myopathy and rhabdomyolysis.
用白話說明這項交互作用的意義
Clarithromycin and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Lovastatin belongs to Cardiovascular.
為什麼會發生
CYP3A4 inhibition by clarithromycin reduces first-pass and systemic clearance of lovastatin
處置方式
Do not combine; choose an alternative to clarithromycin or a statin that is not CYP3A4-dependent such as pravastatin or rosuvastatin, withholding the statin if the macrolide is essential.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clarithromycin 的其他交互作用
Lovastatin 的其他交互作用
常見問題
Can I take Clarithromycin with Lovastatin?
MediHelp rates the interaction as contraindicated. Clarithromycin and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clarithromycin is a strong CYP3A4 inhibitor, and lovastatin depends almost entirely on CYP3A4 for clearance. Exposure rises many-fold, leading to myopathy and rhabdomyolysis.
How serious is the interaction between Clarithromycin and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an alternative to clarithromycin or a statin that is not CYP3A4-dependent such as pravastatin or rosuvastatin, withholding the statin if the macrolide is essential.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
