藥物交互作用
Cobicistat + Lovastatin
嚴重程度: 禁忌併用
Cobicistat and Lovastatin: contraindicated interaction.
最後更新
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摘要
Cobicistat is a potent CYP3A4 inhibitor and greatly increases lovastatin exposure, creating a high risk of myopathy and rhabdomyolysis. The combination is contraindicated.
用白話說明這項交互作用的意義
Cobicistat and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
為什麼會發生
Cobicistat inhibits CYP3A4, blocking lovastatin metabolism.
處置方式
Do not coadminister. Switch to pravastatin or rosuvastatin and titrate carefully.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lovastatin 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Lovastatin?
MediHelp rates the interaction as contraindicated. Cobicistat and Lovastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a potent CYP3A4 inhibitor and greatly increases lovastatin exposure, creating a high risk of myopathy and rhabdomyolysis. The combination is contraindicated.
How serious is the interaction between Cobicistat and Lovastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Switch to pravastatin or rosuvastatin and titrate carefully.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Conivaptan. The full list is on the Lovastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
