藥物交互作用
Clindamycin + Rapacuronium
嚴重程度: 嚴重
Clindamycin and Rapacuronium: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
用白話說明這項交互作用的意義
Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Clindamycin has additive pre- and postsynaptic neuromuscular blocking effects that potentiate non-depolarizing blockade.
處置方式
Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clindamycin 的其他交互作用
常見問題
Can I take Clindamycin with Rapacuronium?
MediHelp rates the interaction as major. Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
How serious is the interaction between Clindamycin and Rapacuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
