藥物交互作用
Clindamycin + Microbiota
嚴重程度: 嚴重
Clindamycin and Microbiota: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Oral fecal microbiota products contain live bacterial spores meant to re-establish the gut flora after Clostridioides difficile infection. Antibacterial agents active against these organisms can suppress engraftment and lower efficacy. Clindamycin has broad anaerobic activity and is itself a major risk factor for C. difficile.
用白話說明這項交互作用的意義
Clindamycin and Microbiota can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Antibacterial activity against the administered live bacterial spores and the resulting flora impairs engraftment and colonization.
處置方式
Complete any antibiotic course before starting the microbiota product, observing the interval in the product labeling. Avoid starting clindamycin during or soon after microbiota therapy unless clearly necessary.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clindamycin 的其他交互作用
常見問題
Can I take Clindamycin with Microbiota?
MediHelp rates the interaction as major. Clindamycin and Microbiota can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral fecal microbiota products contain live bacterial spores meant to re-establish the gut flora after Clostridioides difficile infection. Antibacterial agents active against these organisms can suppress engraftment and lower efficacy. Clindamycin has broad anaerobic activity and is itself a major risk factor for C. difficile.
How serious is the interaction between Clindamycin and Microbiota?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete any antibiotic course before starting the microbiota product, observing the interval in the product labeling. Avoid starting clindamycin during or soon after microbiota therapy unless clearly necessary.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Pancuronium. The full list is on the Clindamycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
