藥物交互作用
Clindamycin + Pancuronium
嚴重程度: 嚴重
Clindamycin and Pancuronium: major interaction.
最後更新
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摘要
Clindamycin can potentiate non-depolarising muscle relaxants such as pancuronium and prolong the blockade. Delayed recovery and respiratory depression have been reported, and the effect may not be fully reversed by anticholinesterases.
用白話說明這項交互作用的意義
Clindamycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clindamycin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
為什麼會發生
Clindamycin has intrinsic neuromuscular blocking activity at pre- and postsynaptic sites that adds to pancuronium.
處置方式
Titrate pancuronium with train-of-four monitoring and keep ventilatory support available until recovery is complete. Consider an alternative antibiotic if feasible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pancuronium 的其他交互作用
Clindamycin 的其他交互作用
常見問題
Can I take Clindamycin with Pancuronium?
MediHelp rates the interaction as major. Clindamycin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin can potentiate non-depolarising muscle relaxants such as pancuronium and prolong the blockade. Delayed recovery and respiratory depression have been reported, and the effect may not be fully reversed by anticholinesterases.
How serious is the interaction between Clindamycin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate pancuronium with train-of-four monitoring and keep ventilatory support available until recovery is complete. Consider an alternative antibiotic if feasible.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
