藥物交互作用
Clopidogrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir
嚴重程度: 禁忌併用
Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Clopidogrel's acyl glucuronide metabolite is a strong CYP2C8 inhibitor, which markedly raises dasabuvir exposure. Higher dasabuvir levels raise concern for QT prolongation. The regimen labeling contraindicates strong CYP2C8 inhibitors.
用白話說明這項交互作用的意義
Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Inhibition of CYP2C8 by the clopidogrel glucuronide metabolite reduces dasabuvir metabolism.
處置方式
Avoid the combination and use an alternative antiplatelet such as prasugrel, if suitable. Seek alternative HCV therapy if clopidogrel is essential.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Clopidogrel 的其他交互作用
常見問題
Can I take Clopidogrel with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as contraindicated. Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Clopidogrel's acyl glucuronide metabolite is a strong CYP2C8 inhibitor, which markedly raises dasabuvir exposure. Higher dasabuvir levels raise concern for QT prolongation. The regimen labeling contraindicates strong CYP2C8 inhibitors.
How serious is the interaction between Clopidogrel and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antiplatelet such as prasugrel, if suitable. Seek alternative HCV therapy if clopidogrel is essential.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Abrocitinib, Acetylsalicylic acid, Apixaban. The full list is on the Clopidogrel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
