藥物交互作用
Apixaban + Clopidogrel
嚴重程度: 嚴重
Apixaban and Clopidogrel: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Adding clopidogrel to apixaban increases the risk of major and gastrointestinal bleeding compared with apixaban alone. The combination is sometimes needed, for example after stenting in patients with atrial fibrillation.
用白話說明這項交互作用的意義
Apixaban and Clopidogrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apixaban belongs to Cardiovascular; Clopidogrel belongs to Cardiovascular.
為什麼會發生
Additive effects of P2Y12 platelet inhibition and factor Xa inhibition.
處置方式
Use only when there is a clear indication, keep the duration of dual therapy as short as possible, and consider a proton pump inhibitor. Monitor for bleeding and hemoglobin.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apixaban 的其他交互作用
Clopidogrel 的其他交互作用
常見問題
Can I take Apixaban with Clopidogrel?
MediHelp rates the interaction as major. Apixaban and Clopidogrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding clopidogrel to apixaban increases the risk of major and gastrointestinal bleeding compared with apixaban alone. The combination is sometimes needed, for example after stenting in patients with atrial fibrillation.
How serious is the interaction between Apixaban and Clopidogrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when there is a clear indication, keep the duration of dual therapy as short as possible, and consider a proton pump inhibitor. Monitor for bleeding and hemoglobin.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
