藥物交互作用
Clotrimazole + Cyclosporine
嚴重程度: 中度
Clotrimazole and Cyclosporine: moderate interaction.
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摘要
Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
用白話說明這項交互作用的意義
Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Clotrimazole may inhibit CYP3A4 and P-glycoprotein, reducing cyclosporine clearance.
處置方式
Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clotrimazole 的其他交互作用
常見問題
Can I take Clotrimazole with Cyclosporine?
MediHelp rates the interaction as moderate. Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
How serious is the interaction between Clotrimazole and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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