藥物交互作用
Bosutinib + Clotrimazole
嚴重程度: 中度
Bosutinib and Clotrimazole: moderate interaction.
最後更新
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摘要
Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
用白話說明這項交互作用的意義
Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Clotrimazole belongs to Anti Fungals.
為什麼會發生
Clotrimazole is a CYP3A4 inhibitor that may reduce bosutinib metabolism.
處置方式
Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clotrimazole 的其他交互作用
Bosutinib 的其他交互作用
常見問題
Can I take Bosutinib with Clotrimazole?
MediHelp rates the interaction as moderate. Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
