藥物交互作用
Cannabidiol + Clotrimazole
嚴重程度: 中度
Cannabidiol and Clotrimazole: moderate interaction.
最後更新
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摘要
Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
用白話說明這項交互作用的意義
Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clotrimazole belongs to Anti Fungals.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of cannabidiol by clotrimazole.
處置方式
Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clotrimazole 的其他交互作用
Cannabidiol 的其他交互作用
常見問題
Can I take Cannabidiol with Clotrimazole?
MediHelp rates the interaction as moderate. Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
How serious is the interaction between Cannabidiol and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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