藥物交互作用
Clotrimazole + Entrectinib
嚴重程度: 中度
Clotrimazole and Entrectinib: moderate interaction.
最後更新
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摘要
Clotrimazole may increase entrectinib concentrations when systemically absorbed, raising the risk of QT prolongation, heart failure and other dose-related toxicities.
用白話說明這項交互作用的意義
Clotrimazole and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clotrimazole belongs to Anti Fungals; Entrectinib belongs to Oncology.
為什麼會發生
Clotrimazole inhibits CYP3A4, the main metabolic pathway of entrectinib.
處置方式
Use topical forms or alternative antifungals where possible. If a CYP3A4 inhibitor is needed, reduce the entrectinib dose per labeling and monitor ECG.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clotrimazole 的其他交互作用
Entrectinib 的其他交互作用
常見問題
Can I take Clotrimazole with Entrectinib?
MediHelp rates the interaction as moderate. Clotrimazole and Entrectinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clotrimazole may increase entrectinib concentrations when systemically absorbed, raising the risk of QT prolongation, heart failure and other dose-related toxicities.
How serious is the interaction between Clotrimazole and Entrectinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use topical forms or alternative antifungals where possible. If a CYP3A4 inhibitor is needed, reduce the entrectinib dose per labeling and monitor ECG.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
