藥物交互作用
Clozapine + Glycopyrrolate
嚴重程度: 中度
Clozapine and Glycopyrrolate: moderate interaction.
最後更新
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摘要
Clozapine has substantial anticholinergic activity, and glycopyrrolate adds peripheral anticholinergic effects. The combination can worsen constipation, potentially leading to ileus or bowel obstruction, and can cause urinary retention, dry mouth and tachycardia.
用白話說明這項交互作用的意義
Clozapine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glycopyrrolate belongs to Respiratory.
為什麼會發生
Additive antimuscarinic effects on gastrointestinal and other smooth muscle and glandular tissue.
處置方式
Monitor bowel function and urinary symptoms and use a bowel regimen as needed. Use the lowest effective glycopyrrolate dose and stop it if signs of obstruction develop.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clozapine 的其他交互作用
Glycopyrrolate 的其他交互作用
常見問題
Can I take Clozapine with Glycopyrrolate?
MediHelp rates the interaction as moderate. Clozapine and Glycopyrrolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine has substantial anticholinergic activity, and glycopyrrolate adds peripheral anticholinergic effects. The combination can worsen constipation, potentially leading to ileus or bowel obstruction, and can cause urinary retention, dry mouth and tachycardia.
How serious is the interaction between Clozapine and Glycopyrrolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms and use a bowel regimen as needed. Use the lowest effective glycopyrrolate dose and stop it if signs of obstruction develop.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
