藥物交互作用
Clozapine + Mexiletine
嚴重程度: 嚴重
Clozapine and Mexiletine: major interaction.
最後更新
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摘要
Mexiletine inhibits CYP1A2, the main route of clozapine clearance, and can substantially raise clozapine levels. This may cause sedation, hypotension, seizures, myocarditis risk and QT effects.
用白話說明這項交互作用的意義
Clozapine and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Mexiletine belongs to Cardiovascular.
為什麼會發生
Mexiletine inhibits CYP1A2-mediated clozapine metabolism.
處置方式
Monitor clozapine levels and sedation, blood pressure and ECG; reduce the clozapine dose if levels rise.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mexiletine 的其他交互作用
Clozapine 的其他交互作用
常見問題
Can I take Clozapine with Mexiletine?
MediHelp rates the interaction as major. Clozapine and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mexiletine inhibits CYP1A2, the main route of clozapine clearance, and can substantially raise clozapine levels. This may cause sedation, hypotension, seizures, myocarditis risk and QT effects.
How serious is the interaction between Clozapine and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clozapine levels and sedation, blood pressure and ECG; reduce the clozapine dose if levels rise.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
