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Mexiletine

Mexiletine is a medicine in the class cardiovascular. It is used for arrhythmias.

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僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

重點資訊

藥物類別
Cardiovascular
ATC 代碼
C01BB02
已知交互作用
121 (禁忌併用: 2 · 嚴重: 16 · 中度: 75 · 輕微: 28)
商品名
1
國家與市場
1

用途

作用方式

Class 1B antidysrhythmic; combines with fast Na channels & thereby inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity

成人常用劑量（仿單摘要）

Ventricular Arrhythmias (Life-Threatening) Initial: 200 mg PO q8hr; may load with 400 mg followed by 200 mg PO q8hr if necessary for rapid control of ventricular arrhythmia

僅摘錄仿單中第一行劑量說明；完整的劑量內容請見 App。

懷孕與哺乳

懷孕
Unknown No adequate human data. Animal studies showed no birth defects but more fetal loss (resorptions) at up to 4 times the human dose. Use only if the benefit outweighs the risk, for example for serious arrhythmias, with fetal monitoring.
哺乳
Safe Passes into milk at levels similar to the mother's blood. US label: consider another way of feeding the infant. LactMed: doses up to 600 mg daily give low milk levels that are not expected to harm the infant.

已通報的副作用

  • Vomiting
  • Nausea
  • Dizziness
  • Ataxia
  • Heartburn

黑框警語

  • National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with asymptomatic non-life-threatening ventricular arrhythmias who had a myocardial infarction (MI) >6 days but <2 yr previously Average duration of treatment w/ encainide or flecainide in CAST was 10 months Applicability of CAST results to other populations (eg, patients without recent MI) is uncertain…

禁忌症

  • Hypersensitivity to mexiletine
  • Cardiogenic shock, preexisting 2°/3° AV block without pacemaker

哪些人需要特別留意

  • Monitor and adjust dose to prevent QTc prolongation
  • Use caution in CHF, hypotension, history of seizures

請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。

重要交互作用 (121)

All 121 interactions, with severity and what to do

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可開啟 Mexiletine 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。

  • Dosing by age, kidney and liver function, and further dose lines
  • Renal and hepatic dose adjustments
  • Paediatric dosing
  • How to give it
  • Pharmacokinetics
  • Patient counselling points
  • Food interactions
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同類別的其他藥品

常見問題

What is Mexiletine used for?

Mexiletine is a medicine in the class cardiovascular. It is used for Arrhythmias.

What side effects have been reported with Mexiletine?

Vomiting, Nausea, Dizziness, Ataxia, Heartburn. Serious warning: National Heart, Lung, and Blood Institute's Cardiac Arrhythmia Suppression Trial (CAST): Excessive mortality or nonfatal cardiac arrest (7.7%) shown with encainide or flecainide compared with placebo (3%) CAST was a long-term, multicenter, randomized, double-blind study in patients with…

Can Mexiletine be taken in pregnancy or while breastfeeding?

Pregnancy: Unknown. No adequate human data. Animal studies showed no birth defects but more fetal loss (resorptions) at up to 4 times the human dose. Use only if the benefit outweighs the risk, for example for serious arrhythmias, with fetal monitoring. Breastfeeding: Safe. Passes into milk at levels similar to the mother's blood. US label: consider another way of feeding the infant. LactMed: doses up to 600 mg daily give low milk levels that are not expected to harm the infant.

What does Mexiletine interact with?

MediHelp lists 121 known interactions for Mexiletine. Contraindicated: 2 · Major: 16 · Moderate: 75 · Minor: 28. The most serious include Fezolinetant, Pimozide, Alosetron.

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