藥物交互作用
Amiodarone + Mexiletine
嚴重程度: 嚴重
Amiodarone and Mexiletine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amiodarone inhibits CYP2D6 and may raise mexiletine levels, and both drugs affect cardiac conduction. The combination can increase the risk of mexiletine toxicity, QT prolongation and proarrhythmia.
用白話說明這項交互作用的意義
Amiodarone and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Mexiletine belongs to Cardiovascular.
為什麼會發生
CYP2D6 inhibition by amiodarone plus additive electrophysiologic effects.
處置方式
Monitor ECG including QTc and consider a lower mexiletine dose; watch for CNS and GI toxicity.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Mexiletine 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Mexiletine?
MediHelp rates the interaction as major. Amiodarone and Mexiletine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone inhibits CYP2D6 and may raise mexiletine levels, and both drugs affect cardiac conduction. The combination can increase the risk of mexiletine toxicity, QT prolongation and proarrhythmia.
How serious is the interaction between Amiodarone and Mexiletine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG including QTc and consider a lower mexiletine dose; watch for CNS and GI toxicity.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
