藥物交互作用
Cyclosporin + Danicopan
嚴重程度: 中度
Cyclosporin and Danicopan: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Danicopan inhibits P-glycoprotein and may increase cyclosporine concentrations. This raises the risk of nephrotoxicity and other cyclosporine adverse effects.
用白話說明這項交互作用的意義
Cyclosporin and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Danicopan belongs to Miscellaneous.
為什麼會發生
Danicopan inhibits intestinal P-glycoprotein, increasing cyclosporine absorption.
處置方式
Monitor cyclosporine trough levels and renal function when starting or stopping danicopan, and reduce the cyclosporine dose if needed.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cyclosporin 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Cyclosporin with Danicopan?
MediHelp rates the interaction as moderate. Cyclosporin and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase cyclosporine concentrations. This raises the risk of nephrotoxicity and other cyclosporine adverse effects.
How serious is the interaction between Cyclosporin and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when starting or stopping danicopan, and reduce the cyclosporine dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
