藥物交互作用
Cladribine + Danicopan
嚴重程度: 中度
Cladribine and Danicopan: moderate interaction.
最後更新
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摘要
Danicopan inhibits BCRP, and cladribine absorption and disposition depend on BCRP. Cladribine exposure may therefore increase, raising the risk of hematologic toxicity.
用白話說明這項交互作用的意義
Cladribine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cladribine belongs to Oncology; Danicopan belongs to Miscellaneous.
為什麼會發生
Inhibition of the BCRP efflux transporter by danicopan increases cladribine bioavailability.
處置方式
Avoid coadministration if possible, or monitor blood counts and lymphocyte counts closely. Consider cladribine dose reduction per labeling.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cladribine 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Cladribine with Danicopan?
MediHelp rates the interaction as moderate. Cladribine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP, and cladribine absorption and disposition depend on BCRP. Cladribine exposure may therefore increase, raising the risk of hematologic toxicity.
How serious is the interaction between Cladribine and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible, or monitor blood counts and lymphocyte counts closely. Consider cladribine dose reduction per labeling.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
