藥物交互作用
Brentuximab + Danicopan
嚴重程度: 中度
Brentuximab and Danicopan: moderate interaction.
最後更新
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摘要
Danicopan inhibits P-glycoprotein, and MMAE from brentuximab vedotin is a P-gp substrate. Exposure to MMAE may increase, raising the risk of myelosuppression and neuropathy.
用白話說明這項交互作用的意義
Brentuximab and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Brentuximab belongs to Oncology; Danicopan belongs to Miscellaneous.
為什麼會發生
P-gp inhibition by danicopan reduces efflux of MMAE.
處置方式
Monitor blood counts and neuropathy during co-treatment. Hold or reduce brentuximab if toxicity emerges.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Brentuximab 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Brentuximab with Danicopan?
MediHelp rates the interaction as moderate. Brentuximab and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein, and MMAE from brentuximab vedotin is a P-gp substrate. Exposure to MMAE may increase, raising the risk of myelosuppression and neuropathy.
How serious is the interaction between Brentuximab and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy during co-treatment. Hold or reduce brentuximab if toxicity emerges.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
