藥物交互作用
Amiodarone + Danicopan
嚴重程度: 中度
Amiodarone and Danicopan: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Danicopan inhibits P-gp and may increase exposure to amiodarone, a P-gp substrate. Higher amiodarone levels could increase bradycardia, QT prolongation and other toxicity.
用白話說明這項交互作用的意義
Amiodarone and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Danicopan belongs to Miscellaneous.
為什麼會發生
Danicopan inhibits intestinal P-gp efflux, increasing amiodarone absorption.
處置方式
Monitor ECG and heart rate, and consider reducing the amiodarone dose if toxicity appears.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amiodarone 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Amiodarone with Danicopan?
MediHelp rates the interaction as moderate. Amiodarone and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and may increase exposure to amiodarone, a P-gp substrate. Higher amiodarone levels could increase bradycardia, QT prolongation and other toxicity.
How serious is the interaction between Amiodarone and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate, and consider reducing the amiodarone dose if toxicity appears.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
