藥物交互作用
Cyclosporin + Letermovir
嚴重程度: 嚴重
Cyclosporin and Letermovir: major interaction.
最後更新
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摘要
Letermovir raises cyclosporine concentrations through CYP3A inhibition, and cyclosporine increases letermovir exposure by inhibiting OATP1B1/3. The combination can cause cyclosporine toxicity and increased letermovir adverse effects.
用白話說明這項交互作用的意義
Cyclosporin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Letermovir belongs to Anti Virals.
為什麼會發生
Letermovir inhibits CYP3A and cyclosporine inhibits OATP1B1/3 transport of letermovir.
處置方式
Reduce letermovir to 240 mg daily when given with cyclosporine. Monitor cyclosporine levels frequently during therapy and after letermovir is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclosporin 的其他交互作用
Letermovir 的其他交互作用
常見問題
Can I take Cyclosporin with Letermovir?
MediHelp rates the interaction as major. Cyclosporin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir raises cyclosporine concentrations through CYP3A inhibition, and cyclosporine increases letermovir exposure by inhibiting OATP1B1/3. The combination can cause cyclosporine toxicity and increased letermovir adverse effects.
How serious is the interaction between Cyclosporin and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce letermovir to 240 mg daily when given with cyclosporine. Monitor cyclosporine levels frequently during therapy and after letermovir is stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
