藥物交互作用
Ergotamine + Letermovir
嚴重程度: 禁忌併用
Ergotamine and Letermovir: contraindicated interaction.
最後更新
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摘要
Letermovir can raise ergotamine exposure by inhibiting its CYP3A-mediated clearance. Higher ergotamine levels increase the risk of ergotism, with severe peripheral vasospasm and tissue ischemia.
用白話說明這項交互作用的意義
Ergotamine and Letermovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ergotamine belongs to Central Nervous System; Letermovir belongs to Anti Virals.
為什麼會發生
Letermovir inhibits CYP3A4, reducing the metabolism of ergotamine.
處置方式
Do not co-administer ergot alkaloids with letermovir; use a non-ergot agent for migraine during letermovir therapy.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Ergotamine 的其他交互作用
Letermovir 的其他交互作用
常見問題
Can I take Ergotamine with Letermovir?
MediHelp rates the interaction as contraindicated. Ergotamine and Letermovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Letermovir can raise ergotamine exposure by inhibiting its CYP3A-mediated clearance. Higher ergotamine levels increase the risk of ergotism, with severe peripheral vasospasm and tissue ischemia.
How serious is the interaction between Ergotamine and Letermovir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer ergot alkaloids with letermovir; use a non-ergot agent for migraine during letermovir therapy.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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