藥物交互作用
Colchicine + Letermovir
嚴重程度: 嚴重
Colchicine and Letermovir: major interaction.
最後更新
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摘要
Letermovir inhibits CYP3A4 moderately and may raise colchicine concentrations. This increases the risk of colchicine toxicity such as myopathy, diarrhea and cytopenias.
用白話說明這項交互作用的意義
Colchicine and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Letermovir belongs to Anti Virals.
為什麼會發生
Letermovir inhibits CYP3A4 (and transporters), reducing colchicine elimination.
處置方式
Reduce the colchicine dose and monitor for signs of toxicity. Avoid the combination in patients with renal or hepatic impairment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Colchicine 的其他交互作用
Letermovir 的其他交互作用
常見問題
Can I take Colchicine with Letermovir?
MediHelp rates the interaction as major. Colchicine and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir inhibits CYP3A4 moderately and may raise colchicine concentrations. This increases the risk of colchicine toxicity such as myopathy, diarrhea and cytopenias.
How serious is the interaction between Colchicine and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the colchicine dose and monitor for signs of toxicity. Avoid the combination in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
