藥物交互作用
Atorvastatin + Letermovir
嚴重程度: 嚴重
Atorvastatin and Letermovir: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Letermovir increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin may also affect letermovir through OATP1B1/3 competition, though this is less important.
用白話說明這項交互作用的意義
Atorvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atorvastatin belongs to Cardiovascular; Letermovir belongs to Anti Virals.
為什麼會發生
Letermovir inhibits CYP3A4 and OATP1B1/3, reducing atorvastatin metabolism and hepatic uptake.
處置方式
Limit atorvastatin to no more than 20 mg daily and monitor for myopathy. Avoid atorvastatin if letermovir is given with cyclosporine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atorvastatin 的其他交互作用
Letermovir 的其他交互作用
常見問題
Can I take Atorvastatin with Letermovir?
MediHelp rates the interaction as major. Atorvastatin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir increases atorvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Atorvastatin may also affect letermovir through OATP1B1/3 competition, though this is less important.
How serious is the interaction between Atorvastatin and Letermovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atorvastatin to no more than 20 mg daily and monitor for myopathy. Avoid atorvastatin if letermovir is given with cyclosporine.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
