藥物交互作用
Cyclosporine + Flibanserin
嚴重程度: 禁忌併用
Cyclosporine and Flibanserin: contraindicated interaction.
最後更新
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摘要
Cyclosporine is a moderate CYP3A4 inhibitor and can raise flibanserin exposure. Higher flibanserin levels increase the risk of severe hypotension, syncope and sedation.
用白話說明這項交互作用的意義
Cyclosporine and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of flibanserin reduces its clearance.
處置方式
Do not combine; flibanserin labeling prohibits use with moderate or strong CYP3A4 inhibitors. Stop flibanserin while cyclosporine is needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Flibanserin 的其他交互作用
常見問題
Can I take Cyclosporine with Flibanserin?
MediHelp rates the interaction as contraindicated. Cyclosporine and Flibanserin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine is a moderate CYP3A4 inhibitor and can raise flibanserin exposure. Higher flibanserin levels increase the risk of severe hypotension, syncope and sedation.
How serious is the interaction between Cyclosporine and Flibanserin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; flibanserin labeling prohibits use with moderate or strong CYP3A4 inhibitors. Stop flibanserin while cyclosporine is needed.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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