藥物交互作用
Danazol + Simvastatin
嚴重程度: 禁忌併用
Danazol and Simvastatin: contraindicated interaction.
最後更新
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摘要
Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
用白話說明這項交互作用的意義
Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Danazol inhibits CYP3A4 and so reduces the metabolism of simvastatin, increasing systemic exposure.
處置方式
Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Simvastatin 的其他交互作用
常見問題
Can I take Danazol with Simvastatin?
MediHelp rates the interaction as contraindicated. Danazol and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Danazol increases simvastatin exposure and has been associated with myopathy and rhabdomyolysis when combined with it. The labeling lists this pairing as contraindicated.
How serious is the interaction between Danazol and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if danazol is required, stop simvastatin or switch to a statin not dependent on CYP3A4. Report any unexplained muscle pain or weakness promptly.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
