藥物交互作用
Cobicistat + Simvastatin
嚴重程度: 禁忌併用
Cobicistat and Simvastatin: contraindicated interaction.
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摘要
Cobicistat is a strong CYP3A inhibitor and greatly increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Labeling contraindicates the combination.
用白話說明這項交互作用的意義
Cobicistat and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
為什麼會發生
Inhibition of CYP3A4-mediated simvastatin metabolism by cobicistat.
處置方式
Do not combine; use an alternative statin such as pravastatin or low-dose rosuvastatin. Stop simvastatin before starting cobicistat.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Simvastatin 的其他交互作用
Cobicistat 的其他交互作用
常見問題
Can I take Cobicistat with Simvastatin?
MediHelp rates the interaction as contraindicated. Cobicistat and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A inhibitor and greatly increases simvastatin exposure, raising the risk of myopathy and rhabdomyolysis. Labeling contraindicates the combination.
How serious is the interaction between Cobicistat and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use an alternative statin such as pravastatin or low-dose rosuvastatin. Stop simvastatin before starting cobicistat.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cyclosporine. The full list is on the Simvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
