藥物交互作用
Darunavir + Simvastatin
嚴重程度: 禁忌併用
Darunavir and Simvastatin: contraindicated interaction.
最後更新
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摘要
Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.
用白話說明這項交互作用的意義
Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Simvastatin belongs to Cardiovascular.
為什麼會發生
Darunavir and its pharmacokinetic booster inhibit CYP3A4, blocking first-pass and hepatic metabolism of simvastatin.
處置方式
Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Simvastatin 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darunavir with Simvastatin?
MediHelp rates the interaction as contraindicated. Darunavir and Simvastatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, substantially raises simvastatin concentrations and the risk of rhabdomyolysis. The combination is contraindicated in labeling.
How serious is the interaction between Darunavir and Simvastatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; stop simvastatin during darunavir therapy and use an alternative such as pravastatin or low-dose atorvastatin or rosuvastatin with monitoring.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
