藥物交互作用
Dapagliflozin + Glimepiride
嚴重程度: 中度
Dapagliflozin and Glimepiride: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Dapagliflozin has a low intrinsic hypoglycemia risk, but together with glimepiride the risk increases. Episodes can be prolonged given the sulfonylurea's duration of action.
用白話說明這項交互作用的意義
Dapagliflozin and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glimepiride belongs to Endocrine.
為什麼會發生
Additive pharmacodynamic glucose lowering through urinary glucose loss and insulin secretion.
處置方式
Consider a lower glimepiride dose when dapagliflozin is started. Monitor blood glucose closely.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Glimepiride 的其他交互作用
Dapagliflozin 的其他交互作用
常見問題
Can I take Dapagliflozin with Glimepiride?
MediHelp rates the interaction as moderate. Dapagliflozin and Glimepiride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin has a low intrinsic hypoglycemia risk, but together with glimepiride the risk increases. Episodes can be prolonged given the sulfonylurea's duration of action.
How serious is the interaction between Dapagliflozin and Glimepiride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower glimepiride dose when dapagliflozin is started. Monitor blood glucose closely.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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