藥物交互作用
Dapagliflozin + Glimepiride-pioglitazone
嚴重程度: 中度
Dapagliflozin and Glimepiride-pioglitazone: moderate interaction.
最後更新
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摘要
Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
用白話說明這項交互作用的意義
Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
為什麼會發生
Additive glucose-lowering through insulin-independent urinary glucose excretion plus sulfonylurea-driven insulin secretion.
處置方式
Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Glimepiride-pioglitazone 的其他交互作用
Dapagliflozin 的其他交互作用
常見問題
Can I take Dapagliflozin with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
How serious is the interaction between Dapagliflozin and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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