藥物交互作用
Chlorpropamide + Dapagliflozin
嚴重程度: 中度
Chlorpropamide and Dapagliflozin: moderate interaction.
最後更新
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摘要
Dapagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide's long duration of action may make hypoglycemia prolonged.
用白話說明這項交互作用的意義
Chlorpropamide and Dapagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Dapagliflozin belongs to Endocrine.
為什麼會發生
Additive glucose lowering from sulfonylurea-stimulated insulin secretion and SGLT2-mediated glucosuria.
處置方式
Consider reducing the chlorpropamide dose when starting dapagliflozin and monitor blood glucose closely, especially in older or renally impaired patients.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Chlorpropamide 的其他交互作用
Dapagliflozin 的其他交互作用
常見問題
Can I take Chlorpropamide with Dapagliflozin?
MediHelp rates the interaction as moderate. Chlorpropamide and Dapagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to chlorpropamide increases hypoglycemia risk. Chlorpropamide's long duration of action may make hypoglycemia prolonged.
How serious is the interaction between Chlorpropamide and Dapagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the chlorpropamide dose when starting dapagliflozin and monitor blood glucose closely, especially in older or renally impaired patients.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
