藥物交互作用
Dapagliflozin + Glipizide
嚴重程度: 中度
Dapagliflozin and Glipizide: moderate interaction.
最後更新
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摘要
Dapagliflozin added to glipizide increases the risk of hypoglycemia. Labeling recommends considering a lower sulfonylurea dose.
用白話說明這項交互作用的意義
Dapagliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glipizide belongs to Endocrine.
為什麼會發生
Additive pharmacodynamic glucose lowering from SGLT2-mediated glucosuria and sulfonylurea-stimulated insulin secretion.
處置方式
Consider lowering the glipizide dose when starting dapagliflozin. Monitor blood glucose and counsel on hypoglycemia.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Glipizide 的其他交互作用
Dapagliflozin 的其他交互作用
常見問題
Can I take Dapagliflozin with Glipizide?
MediHelp rates the interaction as moderate. Dapagliflozin and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to glipizide increases the risk of hypoglycemia. Labeling recommends considering a lower sulfonylurea dose.
How serious is the interaction between Dapagliflozin and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glipizide dose when starting dapagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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