藥物交互作用
Darunavir + Fluticasone-salmeterol
嚴重程度: 禁忌併用
Darunavir and Fluticasone-salmeterol: contraindicated interaction.
最後更新
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摘要
Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and markedly raises salmeterol exposure. This can cause QT prolongation, palpitations and arrhythmias. It also raises systemic fluticasone levels, with a risk of Cushing's syndrome and adrenal suppression.
用白話說明這項交互作用的意義
Darunavir and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Fluticasone-salmeterol belongs to Respiratory.
為什麼會發生
Strong CYP3A4 inhibition by the boosted protease inhibitor reduces salmeterol and fluticasone clearance.
處置方式
Avoid the combination and use a non-CYP3A4-dependent alternative such as a different LABA or ICS (e.g., beclomethasone). If unavoidable, monitor ECG, potassium and adrenal function.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluticasone-salmeterol 的其他交互作用
Darunavir 的其他交互作用
常見問題
Can I take Darunavir with Fluticasone-salmeterol?
MediHelp rates the interaction as contraindicated. Darunavir and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and markedly raises salmeterol exposure. This can cause QT prolongation, palpitations and arrhythmias. It also raises systemic fluticasone levels, with a risk of Cushing's syndrome and adrenal suppression.
How serious is the interaction between Darunavir and Fluticasone-salmeterol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-CYP3A4-dependent alternative such as a different LABA or ICS (e.g., beclomethasone). If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir, Indinavir. The full list is on the Fluticasone-salmeterol page.
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