藥物交互作用
Fluticasone-salmeterol + Ritonavir
嚴重程度: 禁忌併用
Fluticasone-salmeterol and Ritonavir: contraindicated interaction.
最後更新
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摘要
Ritonavir is a potent CYP3A4 inhibitor that markedly increases salmeterol exposure, leading to QT prolongation, tachycardia and arrhythmias. It also substantially raises systemic fluticasone levels, and cases of Cushing's syndrome and adrenal suppression have been reported.
用白話說明這項交互作用的意義
Fluticasone-salmeterol and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluticasone-salmeterol belongs to Respiratory; Ritonavir belongs to Anti Virals.
為什麼會發生
Potent CYP3A4 inhibition by ritonavir reduces clearance of salmeterol and fluticasone.
處置方式
Avoid the combination and use an alternative such as beclomethasone or another non-CYP3A4-dependent regimen. If unavoidable, monitor ECG, potassium and adrenal function.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fluticasone-salmeterol 的其他交互作用
Ritonavir 的其他交互作用
常見問題
Can I take Fluticasone-salmeterol with Ritonavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir is a potent CYP3A4 inhibitor that markedly increases salmeterol exposure, leading to QT prolongation, tachycardia and arrhythmias. It also substantially raises systemic fluticasone levels, and cases of Cushing's syndrome and adrenal suppression have been reported.
How serious is the interaction between Fluticasone-salmeterol and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative such as beclomethasone or another non-CYP3A4-dependent regimen. If unavoidable, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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