藥物交互作用
Deflazacort + Somatrogon
嚴重程度: 中度
Deflazacort and Somatrogon: moderate interaction.
最後更新
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摘要
High-dose glucocorticoids can weaken the growth-promoting effect of growth hormone analogs. Growth hormone also inhibits cortisone-to-cortisol conversion, which may reveal adrenal insufficiency in patients on steroid replacement.
用白話說明這項交互作用的意義
Deflazacort and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Somatrogon belongs to Endocrine.
為什麼會發生
Pharmacodynamic antagonism of growth hormone by glucocorticoids and growth hormone inhibition of 11-beta-HSD1.
處置方式
Monitor growth and keep the glucocorticoid dose as low as clinically possible. Reassess adrenal replacement needs when somatrogon is initiated.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Deflazacort 的其他交互作用
- Adenovirus types 4 and 7 live + Deflazacort 禁忌併用
- Bcg vaccine live + Deflazacort 禁忌併用
- Deflazacort + Influenza virus vaccine quadrivalent intranasal 禁忌併用
- Deflazacort + Measles mumps and rubella vaccine 禁忌併用
- Deflazacort + Measles mumps and rubella vaccine live 禁忌併用
- Deflazacort + Measles mumps rubella and varicella vaccine live 禁忌併用
Somatrogon 的其他交互作用
常見問題
Can I take Deflazacort with Somatrogon?
MediHelp rates the interaction as moderate. Deflazacort and Somatrogon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose glucocorticoids can weaken the growth-promoting effect of growth hormone analogs. Growth hormone also inhibits cortisone-to-cortisol conversion, which may reveal adrenal insufficiency in patients on steroid replacement.
How serious is the interaction between Deflazacort and Somatrogon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor growth and keep the glucocorticoid dose as low as clinically possible. Reassess adrenal replacement needs when somatrogon is initiated.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
