藥物交互作用
Dexamethasone + Mifepristone
嚴重程度: 禁忌併用
Dexamethasone and Mifepristone: contraindicated interaction.
最後更新
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摘要
Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
用白話說明這項交互作用的意義
Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexamethasone belongs to Endocrine; Mifepristone belongs to Endocrine.
為什麼會發生
Glucocorticoid receptor antagonism by mifepristone opposes corticosteroid effect
處置方式
Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Dexamethasone 的其他交互作用
Mifepristone 的其他交互作用
常見問題
Can I take Dexamethasone with Mifepristone?
MediHelp rates the interaction as contraindicated. Dexamethasone and Mifepristone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifepristone is a glucocorticoid receptor antagonist, so it can block the effect of dexamethasone and precipitate adrenal insufficiency in patients who depend on corticosteroid therapy. Reduced corticosteroid effect may also worsen the underlying condition being treated.
How serious is the interaction between Dexamethasone and Mifepristone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Mifepristone labelling contraindicates it in patients on long-term corticosteroids; avoid, or use an alternative route and monitor for adrenal insufficiency symptoms.
What other medicines interact with Dexamethasone?
MediHelp also lists interactions of Dexamethasone with, for example, Bcg vaccine live, Rilpivirine, Smallpox vaccine live. The full list is on the Dexamethasone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
