藥物交互作用
Dexmethylphenidate + Procarbazine
嚴重程度: 禁忌併用
Dexmethylphenidate and Procarbazine: contraindicated interaction.
最後更新 來源: Health Canada product monograph
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摘要
Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
用白話說明這項交互作用的意義
Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Procarbazine belongs to Oncology.
為什麼會發生
MAO inhibition increases stores of catecholamines, so the sympathomimetic effects of the stimulant are exaggerated.
處置方式
Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
參考資料
Procarbazine 的其他交互作用
Dexmethylphenidate 的其他交互作用
常見問題
Can I take Dexmethylphenidate with Procarbazine?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
How serious is the interaction between Dexmethylphenidate and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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