Drug interactions
Dexmethylphenidate + Procarbazine
Severity: Contraindicated
Dexmethylphenidate and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
What this interaction means in plain words
Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dexmethylphenidate belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition increases stores of catecholamines, so the sympathomimetic effects of the stimulant are exaggerated.
What to do
Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dexmethylphenidate + Selegiline Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Procarbazine?
MediHelp rates the interaction as contraindicated. Dexmethylphenidate and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has MAO-inhibiting activity, and dexmethylphenidate releases and blocks reuptake of catecholamines. The combination can provoke a hypertensive crisis with severe headache, arrhythmia, and risk of intracranial haemorrhage.
How serious is the interaction between Dexmethylphenidate and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 14 days of stopping procarbazine. Choose a non-stimulant alternative where needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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